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That same pathway, when chronically overactive, is one of the best-documented drivers of cancer growth and spread, to the point that a class of approved cancer drugs exists specifically to block it
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Fuster et al., 1998), glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and glutathione reductase (Kucharczyk et al., 2023) and X (Malebari et al., 2020), respectively, whereas loop diuretics can interfere with signaling mediated by GABA A receptors (Korpi and Luddens, 1997
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