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Despite their robust multitarget anticancer activities, curcumin, quercetin, resveratrol, and EGCG are characterized by poor aqueous solubility, poor intestinal absorption, extensive metabolism, and systemic clearance ( Advances in biomedical technologies have substantially improved the therapeutic efficacy of NCs against OC by overcoming such major weaknesses, primarily poor bioavailability, short lifespan, decreased tumor targeting, and drug resistance (Zeinali et al., 2025)
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