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With acute asthma exacerbations, these GSH concentrations decreased further and were associated with an increased burden of free radicals and lipid peroxidation byproducts in the plasma and circulating cells (293)
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Moreover, ROS can directly target ETC complexes, especially complex I and complex III, causing electron leakage and amplifying ROS production, which further intensifies oxidative stress and mitochondrial dysfunction [26]
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