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To identify the critical domain of DDX18 required for M12-induced degradation, we generated a fluorescent reporter in which the N-terminal or C-terminal domain of DDX18 were cloned in frame with eGFP followed by an internal ribosome entry site (IRES) and mCherry (Extended Data Fig
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The enzymes that regulate chromatin and DNA modifications are broadly categorized as either “writers”, which add modifications to the target sites, or “erasers”, which remove them(330)
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