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Introduction Depression is a major contributor to the global burden of disease ( Semaphorin 3A (Sema3A) is a secreted protein in the nervous system that is involved in axon guidance ( Sema3A gene are found to be linked to comorbid alcohol dependence and major depression ( Glycogen synthase kinase 3β (GSK3β) is a serine/threonine protein kinase and downstream target of Sema3A ( Epigallocatechin-3-gallate (EGCG) is a catechin polyphenol compound found in tea that has anti-inflammatory, antioxidative, and neuroprotective effects in mammals and may have therapeutic value for the treatment of various diseases ( Although Sema3A, GSK3β, and CRMP2 have been linked to depression, their role in PPD has not been reported