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In addition, in this model microglia seem not to be assigned to a certain phenotype characteristic either for de- or remyelination since most of the genes that were regulated showed an unidirectional up-regulation or down-regulation throughout the de- and remyelination processes (Olah et al., 2012) In respect to the M1/M2 classification it seems that the microglia population in the cuprizone model is either heterogeneously composed of both M1 and M2 phenotypes or microglia display an intermediate status

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As an example, peptide nanosponges (~80 nm) were designed for cell-based cancer therapy [19]