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It has been reported that CFH and ARMS2 SNPs are significantly correlated with early AMD pathogenesis, and it has also been suggested that the polymorphisms of Apolipoprotein E (APOE) are associated with early AMD [106]
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8,25,44,65,247 Interestingly, biosynthesis of the bisepoxide rhizoxin was shown to involve both the bacterial rhi BGC for production of the monoepoxide precursor WF-1360F and a fungal enzyme that catalyzes the final epoxidation leading to rhizoxin (Figure 7)
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