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ATF4 and NRF2 target genes, including xCT, are essential in maintaining cellular homeostasis during amino acid deprivation by increasing mediators of amino acid uptake and stress response such as asparagine synthetase (ASNS), cationic amino acid transporter 1 (CAT1), NAD(P)H:quinone oxidoreductase (NQO1) and glutathione specific γ-glutamylcyclotransferase 1 (CHAC1) [38,46,47,48,49]
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Of the 60 voluntary participants in this study, those who took hyaluronic acid showed a significant reduction in the depth and length of the wrinkles, compared to those who took placebo – as established by microscopic examinations
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