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Indeed, cytosolic iron(II) is believed to possess a control function by influencing the activity of a wide range of cytoplasmic-iron(II)-dependent enzymes [5], including the multitude of iron(II)-dependent 2-oxoglutarate oxygenases associated with histone and nucleic acid demethylation and protein hydroxylation [6]

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One week's treatment with the long-acting glucagon-like peptide 1 derivative liraglutide (NN2211) markedly improves 24-h glycemia and alpha- and beta-cell function and reduces endogenous glucose release in patients with type 2 diabetes