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Autoimmunity, New Potential Biomarkers and the Thyroid Gland—The Perspective of Hashimoto's Thyroiditis and Its Treatment - PMC

Getting (2003) reported a direct head-to-head comparison of core α-MSH peptides (containing HFRW) against the KPV C-terminal fragment in mouse peritonitis: core peptides activated macrophages through melanocortin receptors and elevated cAMP, while KPV failed to elevate cAMP yet reduced immune-cell accumulation comparably [15]

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In particular, bacterial heavy metal transporters display striking homologies and glutathione-binding chemistry to human ABCB7, localized to the inner mitochondrial membrane, which is suggested to export glutathione-coordinated iron–sulfur clusters from mitochondria for use in the cytosol