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These effects include promoting cell survival/proliferation, 52,53 migration/invasion, 53,54 oncogenic transformation, 55,56 and epithelial-to-mesenchymal transition, 54,57,58 as well as promoting tumor angiogenesis 59 and lymphangiogenesis 60 and enhancing a cancer stem cell-like phenotype
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The exact mechanism remains unresolved after decades: no specific receptor, precursor gene, or biosynthetic pathway has been definitively identified
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