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Hypoxia in the HCC also induces the activation of lactate metabolism, serine synthesis pathway and folate cycle, and adenosinergic metabolism to support the growth of tumors (Bao and Wong, 2021)
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In the gut, T cells maintain immune balance, differentiating into proinflammatory (Th1, Th17) or anti-inflammatory [Th2, regulatory T cells (Tregs)] subsets (Dressman and Elyaman, 2022)
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