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When studied as monotherapy in the same trial: 11.5% mean weight loss with cagrilintide 2.4 mg alone versus 3.0% placebo at 68 weeks 60% of participants receiving combination therapy achieved at least 20% weight loss 23% achieved 30% or more weight loss with combination therapy Superior outcomes compared to either agent alone, demonstrating complementary mechanisms Phase 2 dose-finding studies established that cagrilintide 2.4 mg resulted in 10% bodyweight reduction versus 3% with placebo after 26 weeks

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