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This is done by stimulating the expression of two vitally important proteins, arylalkylamine-N-acetyltransferase (AANAT) and the transcriptional protein pCREB
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This amazing discovery, along with subsequent research findings, revealed that the brain RAS is one of many local RASs that mediate intracellular communication among various cell types (a paracrine role) as well as same cell types (an autocrine role) [91,92]
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