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10.1155/2017/2525967 181 LourencoA.M FerreiraL.S BrancoP
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Altered mitochondrial function has been linked to magnesium deficiency by several mechanisms, comprising alterations in coupled respiration [74,75,76], suppression of the antioxidant defense system (e.g., glutathione, superoxide dismutase, catalase, vitamin E) [77,78,79,80,81], increased mitochondrial ROS production [82,83,84], attenuation of pro-survival signaling [85,86,87], triggering of calcium overload through the mitochondrial calcium uniporter [82,88,89], enhancement of mitochondrial ATP-sensitive potassium channel [90], mitochondrial permeability transition pore opening [91], and promotion of inner membrane anion channel [92]
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