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Chronic low-grade inflammation, as observed in aging, estrogen deficiency, and autoimmune disorders such as rheumatoid arthritis, exerts a negative regulatory effect on bone cells through continuous cytokine release, while oxidative stress further exacerbates cellular damage and signaling pathway disruption via the accumulation of ROS ( 2.2 Oxidative stress in osteoporosis Highly reactive molecules that contain oxygen are called reactive oxygen species, or oxygen free radicals
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Although 8-OHdG and 8-epi-PGF2α are classic markers of OS, their elevated levels are not specific to uterine fibroids
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