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In addition, Kim and colleagues’ study [287] revealed that MMP-9 is an epigenetic regulator—it enters the nuclear compartment where it cleaves the histone H3 N-terminal tail (H3NT), promoting osteoclastogenic gene activation (CTSK also may play a role as an epigenetic regulator of osteoclast gene expression [284])
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ACSL4 Inhibitor ACSL4 is an enzyme critical for LPO production and can promote ferroptosis by converting PUFAs to acyl-CoA, especially adrenic acid (C22:4) and arachidonic acid (C20:4) [97,98,99]
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