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In previous studies, FOXO4 and p53 have been shown to interact, a process that inhibits the pro-apoptotic role of p53 by restraining its nuclear exclusion, thereby promoting cell survival
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However, existing treatments for AF, such as drugs and ablation procedures, are prone to side effects, complications, and high surgical recurrence rates, all with their limitations ( Upstream treatment is a new approach to prevent and treat AF with non-antiarrhythmic drugs, which is essentially primary and secondary prevention of AF
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