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These include the protein networks mediated by epidermal-growth-factor receptor (EGFR) [10,11,12,13], tyrosine-protein kinase JAK (JAK), signal transducer and activator of transcription (STAT) (JAK/STAT pathway) [14,15,16], phosphoinositide-3-kinase (PI3K), RAC-alpha serine/threonine-protein kinase (AKT), serine/threonine-protein kinase mTOR (mTOR) (PI3K/AKT/mTOR pathway) [10,17,18], and mitogen-activated protein kinases (MAPK/ERK pathways) [19,20]
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