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MC4R hyperthermia was analyzed as the mean Tb from 120 to 360 min after dosing although, when the preceding hypothermia is long lasting, it affects (reduces) the Tb (120–360)
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The potential metabolism-immune-neuro interaction framework of PEM is based on multi-level molecular crosstalk: mitochondrial dysfunction generates DAMPs that activate innate immune pathways (NLRP3, NF-κB) to induce peripheral inflammation
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