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Arachidonic acid (AA) is a polyunsaturated fatty acid, which could be metabolized by cyclooxygenase (COX) enzymes to produce various pro-inflammatory eicosanoid
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This includes the upregulation of polyketide biosynthesis genes and ESX-1 secretion, which restricts phagosomal acidification and induces phagosomal rupture respectively [72]
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