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The metastatic diagnosis date was the earliest of at least 1 inpatient or at least 2 outpatient claims with diagnoses for secondary malignancies (ICD-9-CM: 196.xx-198.xx, ICD-10-CM: C77.xx-C79.xx) separated by at least 30 days and up to 1 year

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One noticeable benefit is needing to use less lubricating eye drops, which in turn saves money over the long run