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Research indicates: Non-selective CTR and AMYR agonism produces greater weight loss than AMYR-selective compounds CTR activation may enhance metabolic rate and energy expenditure Synergistic effects between AMYR and CTR pathways in weight regulation Distinct receptor dynamics compared to salmon calcitonin, avoiding receptor downregulation The dual AMYR/CTR agonist profile appears optimal for obesity treatment, with clinical data supporting superior efficacy compared to AMYR-selective approaches