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Iron-sulfur cluster deficiency can be sensed by IRP2 and regulates iron homeostasis and sensitivity to ferroptosis independent of IRP1 and FBXL5

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It is interesting to speculate that this may be in part because of a discrepancy between the concentration of alanine in human plasma, where it is the second most abundant amino acid, and in most tissue culture medias, which have little to no alanine [15]