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How It Works (What Makes It Interesting) NMDA & GABA receptor modulation — Research indicates DSIP enhances GABA-activated currents in hippocampal and cerebellar neurons while attenuating NMDA-activated responses in cortical regions, suggesting a dual mechanism for regulating excitatory/inhibitory neural balance HPA axis suppression — Studies consistently show DSIP reduces basal corticotropin (ACTH) levels and blocks stress-induced corticosterone release, pointing to direct modulatory influence over the hypothalamic-pituitary-adrenal (HPA) axis Indirect opioid pathway activation — DSIP does not bind directly to opioid receptors
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The group receiving the combined treatment experienced a 15.6% reduction in weight loss, while the groups receiving treatment with cagrilintide or semaglutide experienced an 8.1% and 5.1% reduction in body weight, respectively [2]
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