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In parallel, directly supporting the GSH/Trx systems—via precursors (cysteine/N-acetylcysteine, selenium for selenoenzymes), enzyme cofactor support, or metabolic rewiring—restores redox buffering and helps the proteome re-enter the “reversible cysteine” zone (see “The cysteine “oxidation code”” section), preserving physiological H 2 O 2 -mediated signalling while preventing spillover into irreversible oxidation (Ren et al

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